BETA · LAUNCHING SUMMER 2026
CLINICAL RESEARCH INTELLIGENCE

Ask the question.
Run the study.
Advance medicine.

The specialty-specific AI platform, built by physicians. Hypothesize. Interpret. Innovate. That's what clinicians and researchers do best. Orpheon, powered by Cantos, handles everything in between.

Join the beta Explore the platform

First 100 clinicians and researchers · Urology and general surgery first, with specialty leads shaping each expansion · Free during beta

Powered by Cantos, Orpheon's proprietary clinical intelligence model

<2 min
Literature gap analysis · Discover
Real Time
Prospective capture · Vault
Hours
Manuscript drafting · Studio
Specialty-trained
Shaped by your peers · Cantos
The intelligence layer

Meet Cantos.

Clinical intelligence, curated for your specialty.

We're building Cantos one specialty at a time. Each discipline starts with an independent foundation: the specialists who practice it, the literature that defines it, the guidelines and consensus documents that govern it. Every answer Cantos returns is shaped by your field's evidence, not averaged across all fields.

0
Papers indexed · Updated continuously
PubMed · Embase · ClinicalTrials.gov · bioRxiv · medRxiv

Trained by specialists

Practicing specialists are shaping Cantos's reasoning one discipline at a time: how the field thinks, which evidence matters, how its journals evaluate work.

Grounded in specialty evidence

Every peer-reviewed paper and every public trial registry across PubMed, Embase, ClinicalTrials.gov, bioRxiv, and medRxiv. Your specialty's guidelines and consensus statements anchor every clinical answer, cited back to the publisher so you read the original, not a paraphrase.

Speaks your field's language

Cantos answers in your specialty's voice and writes to your journals' conventions, not the hedged prose of a general-purpose chatbot.

Why Orpheon

Innovation in every layer.
Engineered to transform medicine.

The path from observation to publication is broken. Not for lack of insight, not for lack of data, but because every layer of the research workflow was built for a different era.

First of its kind clinical research engine

Existing clinical AI tools analyze the published literature to answer clinical queries. In addition to those answers, Orpheon is the first system designed to identify the gaps and the questions yet to be answered, transforming clinicians into medical innovators.

Specialty-trained. Every claim traceable.

General AI tools train on everything and specialize in nothing. Cantos is trained one specialty at a time on the literature, guidelines, trials, and case patterns that define it. Urology and General Surgery first. Every claim Cantos produces links back to its source, with attached citations you can easily verify.

Built for research. Designed for clinicians.

Clinical data tools were built for documentation, not research. Vault reimagines data capture from the clinician's workflow outward. Case-based by structure, prospective by default, accessible from any device. Capture cases by voice at the bedside, monitor cohorts in real time, automate patient-reported outcomes. Vault is designed to surface when your data is mature and how it can contribute.

Defined by your data. The outputs your clinical goals require.

Powered by your data, Studio drafts every artifact your work requires, each trained to meet the variable formats and standards your specialty expects. Manuscripts, grants, protocols, IRB submissions, patient-facing metrics, business plans. Translate your Vault dataset into a polished work product ready to meet your goals.

Secure throughout. On demand accessibility.

Most clinical tools force a tradeoff between privacy and access. Orpheon is being built differently. HIPAA-aligned design and patient privacy form the framework of how the platform is designed. Your data stays under your control, accessible from any device, any time. Privacy and access aren't features. They're the foundation.

Single-site simplicity. Global-scale impact.

Disease processes do not occur in silos. Neither should research. Multi-center collaboration today demands separate databases, custom data exports, and weeks of complex processing. Orpheon is being built to help you identify potential collaborators and let co-investigators across institutions work from one shared Vault structure, with permissioning, attribution, and real-time updates handled within the platform. One secure workflow, whether you run a single-surgeon series or a global registry.

Built on Cantos

Three products.
One methodology.

The gap you find in Discover becomes the question you answer in Vault, where Cantos cross‑references your data against the same literature to flag when it's mature.
The analysis you run in Vault becomes the manuscript you draft in Studio, with citations pulled from Discover. One continuous session, three surfaces, one body of work.

01 Discover

Search every paper.
Find every gap.
Answer any question.

Ask your question in plain language. Cantos searches every major database, ranks every study by relevance, synthesizes the evidence, and turns the gaps into your next research opportunity.

orpheonhealth.com/discover
  • ✓Natural language search. Ask the question the way you'd ask a colleague. Cantos queries PubMed, Embase, ClinicalTrials.gov, and the major preprint and specialty-specific databases in one pass.
  • ✓Relevance Score. Every study is ranked by how directly it answers your question, weighted by evidence quality, study design, and recency. The highest-yield reads sit at the top of the list.
  • ✓Cantos synthesis. The top studies are read, summarized, and coalesced into an evidence-based answer written in the voice of your specialty, with every claim linked back to the source paper.
  • ✓Research opportunity generator. Cantos turns previously unidentified gaps in the literature into your next high-impact research opportunity, with novelty, impact, and feasibility scored. One click carries it into Studio.
  • ✓Cohort feasibility, instantly. Cantos checks your Vault against every surfaced research opportunity, telling you how many matching cases you already have and how soon you'll hit a publishable target N at your current case volume.
  • ✓Literature Radar. Cantos keeps watching the field after you ask. A new trial against your question, a competing series moving the standard, a gap that begins to fill: Discover flags it on your dashboard the morning it hits.
02 Vault

HIPAA-aligned.
Clinician controlled.
Built for practice and research.

One HIPAA-aligned database for every study you run: retrospective series, prospective clinical trials, QI projects, and long-term outcomes tracking. Capture cases by voice, photo, or text input, or import an existing spreadsheet in bulk. Cantos runs your statistics on demand and reports them in plain language. You control the methodology. You own the data.

  • ✓No schema to design. Pick your specialty and your procedures, and the right fields are already there. Vault ships with your curated specialty dictionaries, so you never build a data dictionary or guess your columns up front.
  • ✓One living database, not scattered projects. Enter each patient once. Your studies are saved cohorts over that single corpus, and they keep growing as you log cases. De-identified by design.
  • ✓Capture in seconds, at the bedside. Log a case by voice, by photo of an op note or lab report, or by typing. Cantos structures every entry against your fields. Patient-reported outcomes are fully managed by Vault: it schedules each survey, sends it, and files the response back to the right case, with no added work for you.
  • ✓Cantos-guided statistics, clinician directed. You set the methodology. Cantos runs the analysis, from descriptive summaries to group comparisons, adjusted multivariable models, and survival curves, and translates every result into plain language. The biostatistics you would normally wait on a statistician for, ready the moment your cohort is.
  • ✓Knows when your data is ready. Vault tracks your accumulating series against the literature you queried in Discover, tells you how close you are to your target N, and flags the moment a finding becomes publishable, then hands it to Studio.
  • ✓See where you stand. Compare any outcome three ways: against your own historical baseline, against peer Vaults in your specialty, and against published literature, before a reviewer asks.
HIPAA-aligned
BAA available on request
PHI on-device
Encrypted in transit and at rest
Never sold or shared
PHI never sent to third-party AI
Research is opt-in
Revocable, never includes PHI
03 Studio

Every output imaginable.
Built to your specifications.
Integrated across Orpheon.

Studio is Orpheon's output engine, where your clinical data and research become a polished product. Your Vault and Discover libraries feed the content. You interpret the data. Cantos acts as your research assistant, drafting everything from manuscripts to grant applications to patient-facing graphics. The work moves at your pace, in your voice, under your authority.

orpheonhealth.com/studio/ms-2041
  • ✓Every output, one engine. Manuscripts, grants, IRB protocols, posters, abstracts, and patient-facing graphics all draft from the same Vault data and Discover library, in the same continuous workflow.
  • ✓Publication-grade statistics, built in. Studio runs the analyses your manuscript actually needs (Kaplan-Meier survival, Cox regression, subgroup analysis, multivariable models) and renders the tables and figures alongside the text that interprets them. No third-party software, no switching tools.
  • ✓Cantos learns your voice. The more you write, the more Cantos learns: your phrasing, your structure, your way of interpreting a result. Cantos is the research assistant; you are the principal investigator on every page. The integrity of the work remains yours.
  • ✓Protocol to manuscript, one continuous workflow. Studio designs your protocol from a Discover opportunity. As Vault accumulates the data, Cantos drafts your manuscript outline and content section by section, guided by your input and anchored with citations from your Discover library. You approve every milestone.
  • ✓Critical reviewer and journal fit, on demand. Cantos reads your manuscript end to end for alignment, ranks recommended journals by fit, and predicts acceptance likelihood. Run the critical reviewer pass to tighten the work, then watch the journal ranking and acceptance score recalculate as your manuscript improves.
  • ✓Submission-ready, journal-formatted. Pick the target and Studio formats your manuscript to spec: reference style, structured abstract, figure captions, cover letter, and supplementary files. Studio takes the busy work out of the submission process.
Dashboard

Orpheon's home base.
Where it all comes together.

Today's Brief
Cantos-curated
Sample data
LIT
EAU 2026 update on PSMA-PET imaging before RALP
Relevant to your prostate cancer cohort · 3 papers
COH
Partial nephrectomy cohort crossed n=320
3-month follow-up window opens for 12 patients
TRI
2 trials matched to your active patients this morning
Open in Discover →
Active Projects
3
Sample data
Single-port vs. multi-port RALP, continence at 3 months
Protocol › IRB › Enroll › Analyze
Renal mass nephrometry score and ischemia time in partial nephrectomy
Protocol › IRB › Enroll › Analyze
The role of ICG and thermal imaging in reducing ischemia time in partial nephrectomy
Protocol › IRB › Enroll › Analyze
Saved Concepts
7
Sample data
PSMA-PET in active surveillance triage
Prostate
Cryoablation outcomes in T1a renal masses, 5-year
Kidney
Robotic ureteral reimplant in adults: complication patterns
Reconstruction
Surgeon volume and positive margin rate, multi-institutional
Outcomes
Vault
Live
Sample data
5,401
Total cases captured
Radical Prostatectomy 1,012
Partial Nephrectomy 320
Radical Nephrectomy 80
Pyeloplasty 56
Ureteral Reimplant 28
Benchmarks
vs. national
Sample data
Robotic Prostatectomy · n=1,012
Positive surgical margins 7.4%
Your rateNational baseline 19.0%
Biochemical recurrence, 5-yr 12.8%
Your rateNational baseline 24.0%
Pad-free continence at 3 months 84%
Your rateNational baseline 62%
Community and Education
Feed
Sample data
JS
Dr. J. Sundaram · RALP
Retzius-sparing technique on a 92g gland: my approach for the apex.
12 replies · 48 saves
MR
Dr. M. Ricci · PARTIAL NEPH
Off-clamp PN for hilar T1b: warm ischemia avoidance vs. margin risk.
8 replies · 31 saves
AU
AUA 2026 · CME
Live session: Robotics in Urologic Reconstruction. Earns 1.5 AMA PRA Category 1 credits.
May 16 · 240 attendees
From the founder

Too many good ideas die in case logs.
Most never reach the literature.

Every clinician I know has research that never makes it out of their case logs. I've spent my career as a clinician and a researcher, and I've watched it happen to colleagues I respect and in cases I've cared about. Insight worth publishing, observations worth studying, lost to records nobody else will ever read.

Literature is fragmented. Outcome data is locked inside records built for billing. Statistical software was made for statisticians, not clinicians. Manuscript drafting takes months. And the toolkit to make any of this efficient and accessible for practicing clinicians has never been built.

Orpheon is being built to close that gap. In Discover, you see what the literature already knows, and where it falls silent. In Vault, you capture your data prospectively, structured for research from the first case, with statistical analysis designed for clinicians, not statisticians. In Studio, you seamlessly draft the manuscript, the abstract, the grant. Cantos, the clinical intelligence model behind all three, is trained one specialty at a time on the literature that defines it.

This is the platform I wished I had as a resident, the platform I needed as a young attending, and the platform I am building now as an experienced surgeon. For every clinician who has ever seen something in clinic worth studying, I'd be honored to have you with us as a founding member.

Christopher Russell, MD, FACS Founder, Orpheon Health

Join the beta.

We're hand-selecting the first 100 clinicians and researchers to help shape Orpheon before public launch. Free during beta. No commitment. Have a specialty you'd like Orpheon to support? Tell us below.

Founding cohort progress. Urology and general surgery first.

We'll only email you about Orpheon. No spam, we never sell your data. Unsubscribe anytime. By joining, you agree to our Terms and Privacy Policy.

You're on the list.

We'll be in touch with beta access details in the coming weeks. Meanwhile, follow along. We have a lot to share between now and launch.

HIPAA-aligned
PHI on-device
Never sold
Research is opt-in
FAQ

Questions & answers

When will the beta be available?

Beta access opens mid-2026. We're rolling out specialty-specific waves beginning with General Surgery and Urology, with additional specialties added in subsequent waves. Sign up now to reserve your spot.

Who can join the beta?

Any practicing clinician, researcher, or trainee working in general surgery or urology, including attendings, fellows, residents, medical students, advanced practice clinicians, and PhD researchers. Additional specialties will be added in subsequent waves. You don't have to be actively publishing today. If you've ever seen something in clinic worth studying, you're exactly who we're building for.

What if I don't consider myself a researcher?

Most of the clinicians we're building this for don't, at least not yet. Orpheon is built for every clinician, regardless of practice setting or research experience. For the active clinical researcher, Orpheon streamlines your workflow and amplifies the impact of your work. For the curious clinician, Orpheon is the gateway to translating your ideas, observations, and personal experience into measurable impact. Whether you want to compare your outcomes with others in your specialty, draft a poster or abstract, write a case report, or publish a manuscript, Orpheon generates the information and produces the outputs you need. Orpheon grows with you; there's no day-one expectation of being a researcher.

Is it free?

Yes, free for the duration of the beta. Beta users will also be locked in at founding-member pricing when paid plans launch.

Is there a mobile app?

Orpheon's web app runs on any modern browser, including mobile. A native iOS app is in active development, prioritizing prospective Vault capture and dictation. Beta participants get early access to native builds as they ship.

Is my patient data safe?

Vault is engineered as a de-identified data layer. Patient identifiers are stripped on-device before anything reaches Orpheon's servers, so no PHI ever leaves your device. You control what goes in, and you retain ownership of the data you contribute.

Can I export my data?

Yes, always. Your data is yours. Vault registries export in standard formats (CSV, JSON), and Studio outputs (manuscripts, abstracts, grant applications) export in DOCX or PDF. There's no lock-in: if Orpheon isn't for you, you can take everything you've built.

How is this different from OpenEvidence or other AI tools?

Orpheon is purpose-built to produce research, not just retrieve it. OpenEvidence and similar tools summarize what's already published. Cantos, Orpheon's proprietary clinical intelligence model, identifies what's missing in the literature, structures your prospective data to answer it, and assists you in drafting the manuscript. Different workflow, complementary purpose: literature, data, manuscript, end to end.

Can I use Orpheon for grant writing or conference abstracts?

Yes. Studio drafts NIH, DOD, and foundation grant applications and society abstracts from the same Vault pipeline as your manuscripts. Launch support prioritizes urology and general surgery specialty society formats (AUA, ACS, SAGES).

One platform that compounds with every case you add.

Free during beta. Beta members lock in founding pricing.

Join the beta